The delivery of anti-cancer drugs to the desired or targeted region is one of the most critical and difficult problems faced by today's researchers. Therefore, cyclodextrin-based nanosponge (CD-NS) plays an important role in scientific research on the guided release of anti-cancer drugs. Many anti-cancer drugs with both lipophilic and hydrophilic properties can be integrated or loaded into Nanosponge (NS) for targeting purposes, and ultimately the solubility and the bioavailability of the drug is increased while protecting from environmental influences. NSs prepared by reacting cyclodextrins (CD) with cross-linkers such as carbonyl-diimidazole, diphenyl carbonate, hexamethylene diisocyanate and pyromellitic anhydride are nanosize, cross-linked, non-toxic, porous and stable in high temperature polymers. Having to spherical shapes, swelling properties and porous structures, as well as biologically safe and biodegradable NSs offer higher drug loading than other nano carriers. The main advantages of NS as a nanocarrier in drug delivery systems are due to ability to bind weakly soluble drugs in their three dimensional matrix, increase their bioavailability and the aqueous solubility of water-soluble molecules, protect the degradable substances in their structure and controlled release. NSs can also be used as subsidiary in the preparation of pellets, capsules, tablets, suspensions, solid dispersions, granules or topical dosage forms. In this review article, the importance of CD-NS has been emphasized in terms of showing its properties, preparation methods, a new generation of nanocarrier drug delivery agent and therapeutic applications.
Bergal A, Elmas A, and Akyüz G