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Theoretical Calculation for Removing Tau Protein in Alzheimer Disease

Alzheimer's disease (AD) is the most prevalent form of dementia, which affects people older than 60 years and cause suffering for more than 44 million over the world. Plaques formation is one of the first step in the treatment of this illness. The elimination of the accumulation of these plaques by using the resonance oscillation and heat production of ultrasound’s bubble can reduce the side effect of the neurodegenerative disease. In this paper, the resonance frequency is calculated precisely as a function of the required radius, which is the same as the radius of the plaques in the brain. The results are in good agreement with experimental data and just have a negligible percentage error, less than 0.67%. These results can help in modeling accurate frequency for mechanical treatment before in vivo treatment which can reduce the harmful side effects and other healthy cells damage.


Behrouz AH, Zareyi H, Zhour K, Tashakori SH and Vaezzadeh M

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