Chinese oak tasar Antheraea pernyi silk fibroin nanoparticles are a promising biomaterial for drug delivery because of its good properties, such as biodegradability and biocompatibility. In recent decades, self-assembling nanoparticles derived from Antheraea perny silk fibroin have risen too much interest in application of drug delivery. In this paper, the Ca2+ in calcium gluconate induced self-assembling nanoparticles. It was fabricated by blending aqueous Antheraea perny silk fibroin solution, calcium ion and insulin in a proper mixing ratio. The structure of the silk nanoparticles carried insulin was characterized by X-ray diffraction, FTIR and DTA. The size and the morphology of silk nanoparticles were tested using scanning electron microscope and particulate size description analysers. The drug content, covering rate and in vitro cumulative release of silk nanoparticles were also determinate. The results demonstrated that the Ca2+ induced selfassembling nanoparticles hold the particle size of 200~500 nm. The phenomenon of the sustained release is comparatively obvious in the silk nanoparticles. To summarize, this research will open up a new experimental basis on the usage of macromolecular drug, insulin which can properly meet the satisfaction of the patients desired for sustained-release insulin.
Xiang Xue, Hua Fu and Shenzhou Lu
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